Scaffolds for 3D Cell Culture and Cellular Agriculture Applications Derived from Non-Animal Sources

Overview

Who: Santiago Campuzano and Andrew E. Pelling

Published: May 17, 2019

Where: Frontiers in Sustainable Food System

Key Takeaway: These three animal-free biomaterials could have many benefits as scaffolding for cultured meat.

Research Topics: scaffold

Summary

In this review, Santiago Campuzano et al. present three animal-free scaffolds that could be used to grow cultured meat: cellulose, chitin/chitosan, and recombinant collagen. First, the authors look at decellularized plant tissue as a scaffold, detailing its wide array of varying biochemical, topographical and mechanical properties. They then outline the many desirable qualities of fungal chitosan, including synergistic bactericidal effects and improved cell-matrix interaction. Finally they review recombinant collagen as a scaffold, which has the potential to better recapitulate the extracellular matrix. Campuzano et al. offer an overview of three promising biomaterials for scaffolding of cultured meat, while encouraging the reader to learn more about the challenges and noting that scale-up of these techniques is still uncertain.

Written by Nick Johnson

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Campuzano, S., & Pelling, A. E. (2019). Scaffolds for 3D Cell Culture and Cellular Agriculture Applications Derived From Non-animal Sources. Frontiers in Sustainable Food Systems, 3, 38. https://doi.org/10.3389/fsufs.2019.00038

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