Key Takeaway: 3D bioprinting may be the best way to create microvasculature that is functional and physiologically similar to in vivo microvasculature.
Research Topics: scaffold
Jernej Vajda et al. review the current state of microvascular tissue engineering methods. This paper examines the best materials, cells, and scaffold production methods to form vessels on a microscale. Both top-down and bottom-up methods of creating microvasculature are discussed. Vajda et al. see a top-down approach – particularly involving 3D bioprinting – as the more promising technology for the control of structure it offers. They explore traditional extrusion bioprinting, as well as the potential of stereolithography. The paper also briefly touches on the mathematical modeling of the biophysical properties of the microvasculature and the monitoring of tissue functionality with engineered microvasculature.