Sr2+ vs. Ca2+ as post-processing ionic crosslinkers: Implications for 3D bioprinting of polysaccharide hydrogels in tissue engineering

Overview

Who: Jernej Vajda, Boštjan Vihar, Laura Činč Ćurić, Uroš Maver, Matej Vesenjak, Polona Dobnik Dubrovski, Marko Milojević

Published: February 3, 2023

Where: Journal of Materials Research and Technology

Key Takeaway: A systematic comparison of two crosslinking agents for tissue engineering scaffols.

Research Topics: scaffold

Summary

Many scaffold materials, including the commonly used alginate- and cellulose-based materials, require crosslinking to form the material into a usable scaffold. Ca2+ is the most widely used crosslinker, however the authors hypothesize that it’s use may interfere with the development and behavior of tissues because of it’s important role in cell signaling. Vajda et al. test Sr2+ as an alternative option, providing a systematic comparison of the two crosslinking agents to improve our understanding of their applications in tissue engineering.

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Vajda, J., Vihar, B., Ćurić, L. Č., Maver, U., Vesenjak, M., Dubrovski, P. D., & Milojević, M. (2023). Sr2+ vs. Ca2+ as post-processing ionic crosslinkers: Implications for 3D bioprinting of polysaccharide hydrogels in tissue engineering. Journal of Materials Research and Technology.

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