Decellularized Grass as a Sustainable Scaffold for Skeletal Muscle Tissue Engineering

Overview

Who: Scott J. Allan, Marianne J. Ellis, Paul A. De Bank

Published: May 31, 2021

Where: Journal of Biomedical Materials Research Part A

Key Takeaway: Decellularized grass is an attractive scaffold option for cultured meat. Not only is it cheap and readily available, its grooves help promote myofiber alignment.

Research Topics: scaffold

Summary

Scott J. Allan et al. investigate the possibility of using decellularized grass as a scaffold for cultured meat. They specifically examine the scaffold’s impact on skeletal muscle growth, differentiation, and alignment. A decellularized grass scaffold is compared to native grass in growing C2C12 cells. Allan et el. find that the ridges in the decellularized grass promote nuclear alignment, cell alignment, and formation of aligned, multinuclear myotubes. The decellularized scaffold was also superior in supporting cell attachment and growth compared to the native grass. This paper suggests that decellularized grass may be a favorable scaffold for the tissue engineering of skeletal muscle tissue or other tissues.

Written by Morgan Ziegelski

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Allan, S. J., Ellis, M. J., & De Bank, P. A. (2021). Decellularized grass as a sustainable scaffold for skeletal muscle tissue engineering. Journal of Biomedical Materials Research Part A, 1–12. https://doi.org/10.1002/jbm.a.37241

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