- Cite This Publication
Who: Che J. Connon, Ricardo M. Gouveia
Published: February 15, 2021
Where: Advanced Sciences
Key Takeaway: Curved surfaces promote cell alignment and differentiation, and result in denser, more compact muscle tissue.
Che J. Connan & Ricardo M. Gouveia propose the use of miliscale curved surfaces for improving myoblast migration, proliferation, orientation, and differentiation. The study used concave hemicircles 7.5–15 mm in diameter created from glass tubes, compared to planar glass scaffolds. Connan & Gouveia confirm that the curvature promotes myoblast differentiation and alignment. The tissues on the curved surfaces are also found to be more dense and compact. This study raises curved scaffolds as a possibility for cultured meat scaffold design, and it also provides clues to mechanisms of muscle tissue formation and healing.
Written by Morgan Ziegelski
Connon, C. J., & Gouveia, R. M. (2021). Milliscale Substrate Curvature Promotes Myoblast Self‐Organization and Differentiation. Advanced Biology, 5(4), 2000280. doi:10.1002/adbi.202000280
Jernej Vajda, Boštjan Vihar, Laura Činč Ćurić, Uroš Maver, Matej Vesenjak, Polona Dobnik Dubrovski, Marko Milojević
Isha Datar, Mirko Betti
Irfan Tahir, Rachael Floreani